Cancer and causal or contributory genes

Hereditary prostate cancer 1 on Chromosome 1. Accounts for 1 in 500 cases of prostate cancer.

Retinoblastoma - caused by the RB1 gene on Chromosome 13. The protein surpresses the activity of genes involved in cell growth and division. Mutations cause retinoblastoma, a cancer of the eye which usually appears in children under the age of five.

BRCA2 is found on the Chromosome 13 and is involved in the repair of DNA strands.

BRCA1 is found on chromosome 17 and works with BRCA2 to repair DNA strands.

p53 on chromosome 17 is a tumour suppressor gene. Acts as a stop signal for sell division. Mutations are found in most types of cancer.

This is a page from www.genefaith.org created by A. J. Palmer.
This page was updated on 2nd December 2002