Haemophilia - a brief outline of genetic connections

On Chromosome X factor VIII and IX.

These are blood clotting factors and mutations cause haemophilia A and B respectively.


pg 132 Babel's Shadow, Pete Moore

Human Factor IX (sometimes called Christmas Factor) is a protein that is missing in some people who have haemophilia. Without this protein in their blood any cuts or bruises that they may get in day-to-day life bleed for mnay hours. Conventional ways of obtaining clotting factors from donated human blood are costly and carry the risk of introducing some new infection to the recipient.

Hope for gene therapy

There is good hope that gene therapy may become available for haemophilia. "There are several different approaches that are being tested in haemophilia patients. Some scientists now theorise that different vectors - the weakened viruses used to deliver a gene into the body's cells - will be required for different types of haemophilia. But many gene therapists say they are more optimistic about eventually being able to treat haemophilia using gene therapy.

"That will be one of the first genetic diseases that i think gets us all a cure that is reproducible and reliable through gene therapy."  said Dr. Davie Russell, and associate professor of medicine at the university of Washington in Seattle.

John Scheizer, Reuters, 04/06/01

This is a page from www.genefaith.org created by A. J. Palmer.
This page was updated on 2nd December 2002